DeQuervain's disease is an inflammation of the tendons at the base of the thumb that help move the thumb away from the hand. The lining or sheath around the tendons can swell, causing pain with certain thumb and wrist movements. Pain is localized at the thumb side of the wrist, especially with grasping or twisting. This condition may be caused by overuse, trauma or disease, and is more common in women than in men, especially new mothers (positioning and holding infants). DeQuervain's disease can be diagnosed through physical exam. Treatment for this condition focuses on relieving pain and minimizing swelling. Treatment may include anti-inflammatory medication, corticosteroids, splints/orthoses and rest. Surgery to make more room for irritated tendons may be recommended for severe cases that fail conservative management.